2018, Cilt 34, Sayı 4, Sayfa(lar) 290-293
Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep
Ramazan Yıldız1, Orhan Çorum21, Orkun Atik3, Duygu Durna Çorum2, Merve İder4, Mahmut Ok4, Kamil Üney5
1Mehmet Akif Ersoy Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Burdur, Türkiye
2Kastamonu Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Kastamonu, Türkiye
3Afyon Kocatepe Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Afyonkarahisar, Türkiye
4Selçuk Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye
5Selçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, Türkiye
Keywords: Sheep, diclofenac sodium, meloxicam, coagulation

Aim: The aim of this study is to determine the effects of diclofenac sodium and meloxicam administrations on coagulation parameters in sheep.

Materials and Methods: This study was carried out on 12 Akkaraman healthy sheep and they were divided into two groups as the diclofenac sodium group (DS) and meloxicam group (MS), equally. In the DS group, diclofenac sodium (2.5 mg / kg) and in MS group, meloxicam (0.5 mg / kg) was administered intramuscularly once daily for 3 days. Blood samples were taken before the drug administration (0 h) and at 72 hours following administration. The plasma fibrinogen, activated partial thromboplastin time (APTT), prothrombin time (PT), D-dimer and platelet count (PLT) levels were determined at 0 and 72 hours.

Results: During the study, there was no difference in the clinical examination findings of the groups. No statistically differences (P > 0.05) were found in fibrinogen, APTT, PT, D-dimer, and PLT parameters in the DS and MS groups at 0 and 72 hours.

Conclusion: It may be stated that administrations of diclofenac sodium and meloxicam for 3 days in sheep may not cause any change in the coagulation parameters.