2019, Cilt 35, Sayı 2, Sayfa(lar) 066-070
The effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity
İhsan Kısadere1, Nurcan Dönmez2
1Balıkesir University, Faculty of Veterinary Medicine, Department of Physiology, Balıkesir, Turkey
2Selcuk University, Faculty of Veterinary Medicine, Department of Physiology, Konya, Turkey
Keywords: Antioxidants, blood parameters, cadmium, quercetin, rats
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Aim: The aim of this study was to determine the effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity.

Materials and Methods: Adult male “Wistar-Albino” rats (n = 30) were used and divided into four groups as Control (C, n = 6), Cadmium (Cd, n = 8), Quercetin (Q, n = 8) and Cadmium + Quercetin (Cd + Q, n = 8). Cadmium chloride (CdCl2, 4 mg/ kg daily, s.c) were administrated to Cd and Cd+Q groups, and Quercetin (Q, 50 mg/kg daily, i.p) were given to Q and Cd + Q groups for 3 days, respectively. Control group was not recieved any treatment. Blood samples were collected from all animals at fourth day after treatments.

Results: The levels of serum SOD, MDA, GSH, catalase, and plasma ALT, AST, GGT, total protein, albumin were detected. Although, serum MDA levels were found higher (P< 0.05) in Cd than the other groups, it was similiar in Q and C groups. ALT, AST and GGT enzyme levels were observed higher in Cd than C and Q groups (P< 0.05).

Conclusion: Negative effects of acute cadmium toxicity on antioxidan system and some hematological parameters were ameliorated with quercetin treatment in rats.