In the present study, effects of different doses of dietary Cu and Zn supplementation on live weight and feed efficiency and tissue biochemical parameters in broilers were investigated, In this study, a total of 430 Avian Broiler chicks were used and divided into 12 groups as control and treatment groups in which different doses of Cu, Zn and Cu+Zn supplemented. Live weight and leed efficiency were determined at the 1 stT 14th, 28th and 42nd days of age, also tissue samples were collected a! the 14th, 30th and 42nd days of age and Cu, Zn levels were determined. The highest Zn values were determined in 8th group that is the highest Zn supplemented, and there were changes between the groups at the 14th day and 30th day in liver while only at the 42nd day in kidney. The values of Zn increased in bursa of Fabricius at the 30th and 42nd days. I! may be spaculated (hat Cu and Zn supplementation have positive effects on yield performance of broilers.