This study was conducted to determine the protective effects of prednisolone and vitamin E on the development of endotoxin-induced disseminated intravascular coagulation (DIC) in rabbits. Experimental DIC was induced in all groups by intravenous infusion of 100 pg/kgtı lıpopoiysaccharide (E coir 0111 ;B4, LPS) for 6 h in 60 ml saline (10 ml/h). Vitamin E was injected (10 mgkgjp) for 4 successive days, and LPS was infused 10 min after the final vitamin E injection. Prednisolone was injected (10 mg/kg,SC) 30 min before the administration of LPS. Hemostatical and hematological markers at 0, 2,4, and 6 hr were determined. In this study, in the rabbits only receiving endotoxin we observed an important prolongation in APTT, PT and TT, and a decrease in platelet count and librtnogen level, and an increase in D-dimer concentration, and leukophenia, and also significant changes in the percentage of differential leukocytes at sampling times. However, the administrations of prednisolone and vitamin E significantly caused the suppression on the determined parameters. We have suggested that the treatments of prednisolone and vitamin E may bo useful in LPS-induced DIC, and we h3ve concluded thai prednisolone has more effective than vitamin E.