Arthritis is an important disease for dog health concerning about multifactorial etio-patogenesis and different types. Degenerative osteoarthritis (OA) and inflammatory rheumatoid arthritis (RA) are common in the dog, therefore, that are more crucial. It is determined that osteoarthritis is 13 % of all arthritis. And osteoarthritis is also accounting for approximately 37 % of all lameness. Both osteoarthritis and rheumatoid arthritis are characterised by joint cartilage loss. In this review, it is mentioned that diagnosis, etiologisis, patogenesis, clinical examinations and treatment of both osteaarthritis and rheumatoid arthritis. Thus, this review is mainly targetting effect of matrix metalloproteinases (MMP) during the disease process and it is also stated inhibition of MMPs by locally and systematic proceed for arthritis treatment.