This study was carried out to compare the sole and combine effects of cysteine, methionine, cobalt chloride, sodium thiosulphate and sodium nitrite used in the treatment of sheep poisoned with selenium. In the investigation, the changes occurred in the levels of selenium in the blood samples were determined. In the experiments, 66 sheep, at the age of approximately two years were used. The animals on which the experiments were made were fasted from 5.00 pm a day ago to the complement of experimental the next day. Thus, selenium contamination due to feed and water as prevented. Selenium was intramuscularly given at the dose of 0.6 mg/kg. Cysteine, methionine, cobalt chloride, sodium thiosulphate and sodium nitrite were given 30th min before the intravenous selenium administration. Cysteine, methionine, cobalt cloride, sodium thiosulphate and sodium nitrite decreased the levels of selenium in the blood from 2.63 ppm to 1.82, 1.76, 2.14, 1.70 and 2.03 ppm in 30th min, respectively. On the other hand, cysteine+methionine, cysteine+cobalt chloride, methionine+cobalt chloride, cysteine+methionine+cobalt chloride and sodium thiosulphate+sodium nitrite decreased the levels of selenium in the blood from 2.63 ppm to 1.21, 1,21, 1.68, 1.24 and 1.79 ppm in 30thmin, respectively. In conclusion, cysteine+methionine +cobalt cloride and other combinations used in the treatment of selenium poisoning were found to be more effective than cysteine, methionine, cobalt cloride, sodium, thiosulphate and nitrite.