2010, Cilt 26, Sayı 1, Sayfa(lar) 021-024
Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice
Ender Yarsan1, Arif Altıntas2, Dinc Essiz3, Levent Altintas1, Mert Pekcan2, Gulay Ciftci4, Ishraga G. Ibrahim5
1Department of Pharmacology and Toxicology, Ankara University, Faculty of Veterinary Medicine, Diskapi, Ankara, Turkey
2Department of Biochemistry, Ankara University, Faculty of Veterinary Medicine, Diskapi, Ankara, Turkey
3Department of Pharmacology and Toxicology, Kafkas University, Faculty of Veterinary Medicine, Kars, Turkey
4Department of Biochemistry, Ondokuz Mayis University, Faculty of Veterinary Medicine, Samsun, Turkey
5Central Veterinary Research Laboratories, Khartoum, Sudan
Keywords: Sulphamethoxazole, pharmacokinetic, renal failure, mercury chloride
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Aim: The effects of renal failure on the pharmacokinetics of sulphamethoxazole were investigated after oral administration of 100 mg/kg of the drug using a mice model of mercury chloride-induced renal failure. Materials and Methods: Mercury chloride was given to mice at the doses of 3 and 6 mg/kg. Plasma sulphamethoxazole concentrations were measured by spectrophotometer. Plasma concentration-time data were fitted to a two-compartment open model. Results: Significant findings (p<0.05) were observed for absorption (AUC and t1/2a) and elimination (t1/2β and MRT) phases of sulphamethoxazole related with renal failure. Also area under the curve value decreased, and mean residence time value increased with renal failure (p<0.05). Conclusion: Study result showed that dosage and administration intervals of sulphamethoxazole were important for patients with renal failure.