2011, Cilt 27, Sayı 2, Sayfa(lar) 099-105
The production and development of vaccines for Ornithobacterium rhinotracheale infection in commercial broilers
Osman Erganiş, Hasan Hüseyin Hadimli, Kursat Kav, Zafer Sayin
Department of Microbiology, Faculty ofVeterinary Medicine, Selcuk University, Campus, Konya, Turkey
Keywords: Ornithobacterium rhinotracheale, broiler chicken, vaccine, ginseng
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Aim: The purpose of this study was to prepare bivalent inactive Ornithobacterium rhinotracheale [O. rhinotarcheale) bacterin vaccines, to measure the levels of antibodies against antigens in blood sera and to determine the efficacies of different O. rhinotracheale vaccines in broilers.

Materials and Methods: The bivalent inactivated O. rhinotracheale bacterin vaccines were prepared from O. rhinotracheale serotype A and B strains using aluminium hydroxide (Al[OH]3), mineral oil (MO), aluminium hydroxide + ginseng (Al[OH]3 + G) and mineral oil + ginseng (MO + G). After the sterility and the safety tests, laboratory efficiencies of vaccines (challange/protection and serological potency) were controlled on the broilers (vaccinated at first day with a dose of 0.1 mL).

Results: According to the challenge results, all the vaccines were found to be effective as 100% for broilers. The vaccine containing mineral oil and ginseng (MO + G) as adjuvant induced significantly greater humoral immune response to the antigens than others.

Conclusion: The study showed that vaccination of broilers chicken at the first day age may effectively protect against O. rhinotracheale infections.