The present experiment was carried out to compare the effects of cobaltous chloride and sodium thi-osulfate used in the treatment of sheep poisoned with amygdalin. In the study, changes occuring levels of cyanide in the rumen liquor and levels of cyanide, thiocyanate, hemoglobin and methemoglobin in the blood, were determined. In the study, sixteen ewes. aged approximately two years old, were used. The animal on which the experiment was made was fasted from 5 p.m. a day ago to the complement of experiment the next day. Thus, eyanide contaminations due to feed and water were prevented. Amygdalin was given through the rumen probe in the doses of 1,5 mg/kg. Samples of rumen and blood were collected at 1,2,4,8,24, 48 and 72. hours after amygdalin was given. Samples of the rumen were analysed in terms of the levels cyanide. Samples of the blood were analysed in terms of the levels cyanide, thiocyanate, hemoglobin and methemoglobin. lt was observed that sodium nitrite given in the doses of 5,15 and 25 mg/kg at thirty minutes decreased the level of eyanide from 0,21O uglml to 0.082, 0.108 and 0.115 ug/ml at first hour, respectively. On the other hand, it was defined that cobatous chloride given in doses of 5, 10 and 15 mg/kg at thirty minutes decreased the level of cyanide from 0.210 ug/ml to 0.031, 0.037 and 0.056 ug/ml at first hour, respectively. lt was established that cobaltous chloride + sodium nitrit given in the dose of 15+25 mg/kg at thirty minutes decreased the level of cyanide from 0.210 ug/ml to 0.075 ug/ml at first hour. Cobaltous chloride used in the treatment of the cyanide poisoning was determined to be more effective than sodium nitrit.