2014, Cilt 30, Sayı 2, Sayfa(lar) 068-071 | |
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Effect of alcoholic extract of Tarantula cubensis (Theranekron®) on serum thiobarbituric acid-reactive species concentrations in sheep | |
Burak Dik1, Ayşe Er1, Orhan Çorum2 | |
1Selçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, Türkiye 2Dicle Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Diyarbakır, Türkiye |
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Keywords: Tarantula cubensis, thiobarbituric acid-reactive species, safety, sheep | |
Abstract | |
Aim: The aim of the current research was to evaluate the
effect of alcoholic extract of Tarantula cubensis on serum
thiobarbituric acid-reactive species concentrations in sheep.
Furthermore, it's effect on the hematological and biochemical
values were determined. Materials and Methods: Six Akkaraman sheep were administered single dose (6 mL/sheep, SC) of alcoholic extract of Tarantula cubensis. Blood samples were obtained before (0 hour, control) and 2, 4, 8, 12, 24 and 48 hours after administration. Serum thiobarbituric acid-reactive species concentrations were measured by ELISA reader. The concentrations of biochemical and hemogram values were measured by autoanalyzer and blood cell counter, respectively. Results: Alcoholic extract of Tarantula cubensis dramatically decreased on serum thiobarbituric acid-reactive species concentrations in sheep but no statistically significant. In addition, it had no any negative effect on the hematological and biochemical values. Conclusions: It is stated that alcoholic extract of Tarantula cubensis may cause antioxidant effect and it may be accepted safe in sheep when evaluation of short time duration was considered. |
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