2020, Cilt 36, Sayı 5, Sayfa(lar) 059-064
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): pathogenesis and virus-host interactions
Hasbi Sait Saltık, Kamil Atlı, Mehmet Kale
Mehmet Akif Ersoy University, Veterinary Faculty, Department of Virology, Burdur, Turkey
Keywords: Coronavirus, pathogenesis, interaction, host, ace2
Coronaviruses have posed a global threat in three different periods over the past two decades. Severe Acute Respiratory Failure Syndrome (SARS-CoV) was first revealed in 2003. Then, in 2012, Middle East Severe Acute Respiratory Failure Syndrome (MERS-CoV) was detected. In late 2019, it was reported that Coronavirus 2 (SARS-Cov-2) was isolated from Severe Acute Respiratory Failure Syndrome. SARS-Cov-2, which causes a much more severe and common infection compared to SARS-Cov and MERS-Cov, remains a global threat until the vaccine is developed. Owing to the ongoing outbreak of SARS-Cov-2, many facts regarding virus-host interactions and pathogenesis of disease, still needed to be addressed in more detail.
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