The material of this case is a 4-years-old Siberian Husky bitch with 3 months of continuous postpartum bloody vaginal discharge complaints. There were subcutaneous masses in various sizes in many points, vaginal bloody discharge, edematous vulva with fragile and easily bleeding on touch, cauliflower looking tumoral masses as noticed during physical examination. Typical transmissible venereal tumor (TVT) cells, shaped round, ovoid or polyhedral with eosinophylic vacuole, thin cytoplasm, round hyperchromatic nucleus and nucleolus were observed on cytological examination of smears prepared from tumoral masses in vagina. There were changes in echogenities of liver, spleen and left kidney, hepatomegaly, spleenomegaly and besides many mass formations in liver and one in spleen on ultrasonographic examinations. Disseminated metastasized TVT was diagnosed in the bitch depending on clinical, laboratory, radiographic and ultrasonographic examinations. Prognosis of the case was bad thus the patient was euthanized. Metastasized masses were observed during necropsy in skin, subcutaneous and around the udders, on the last rib, in abdomen, lung, liver and spleen. It was observed that TVT case, which is benign usually and metastatic rarely, turned malign and metastasized to skin, subcutaneous tissue, udders, liver, spleen and lung. In conclusion, a careful systemic examination and inquiring the presence of metastasis should be considered in dogs with TVT.