Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats

eng Selçuk Üniversitesi Veteriner Fakültesi Eurasian Journal of Veterinary Sciences 1309-6958 2146-1953 2024-03-08 40 1 1 9 1440 article Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats Sercan Kaya 1 Tuba Yalcin 1 Batman University, Vocational School of Healthcare Studies, Batman, TürkiyeAim: Cisplatin (CIS), an antineoplastic agent, shows serious side effects such as hepatotoxicity. Thymoquinone (ThQ) is a powerful anti-oxidant with many beneficial effects such as anti-inflammatory, anti-tumoral. The aim of this study was to investigate whether ThQ treatment has hepatoprotective effect in CIS-induced hepatotoxicity model in rats and also to determine how CIS and/or ThQ treatments affect OTULIN levels, one of the deubiquitinases, in liver tissue. Materials and Methods: The 28 rats used in the study control (application not done), CIS (7 mg/kg CIS, first day of experiment, intraperitoneal), CIS+ThQ (7 mg/kg CIS, first day of experiment, intraperitoneal + 10 mg/kg/day ThQ, oral gavage) and ThQ (10 mg/kg/day ThQ, oral gavage) were divided into four equal groups (n=7). The experiment was terminated upon completion of all applications (day 15). The effects of CIS and\or ThQ apps on liver tissues were examined biochemically, histopathologically and immunohistochemically. Results: CIS application increased liver enzyme levels, histopathological changes, inflammation, oxidative stress and apoptosis in liver tissue and caused a decrease in OTULIN level. However, ThQ administration showed a positive regulatory effect on CIS-induced changes in liver tissue.. Conclusion: ThQ supplementation has a hepatoprotective effect against CISinduced liver tissue damage. http://eurasianjvetsci.org/pdf.php3?id=1440 Hepatotoxicityotulincisplatinthymoquinone eng Selçuk Üniversitesi Veteriner Fakültesi Eurasian Journal of Veterinary Sciences 1309-6958 2146-1953 2024-03-08 40 1 10 15 1441 article Evaluation of antihyperlipidemic effect of rosemary oil in streptozotocin-induced diabetic rats Deniz Uluisik 1 Ercan Keskin 1 Selcuk Univercity, Veterinary Faculty, Department of Physiology, Konya, TürkiyeAim: In this study, the potential effects of rosemary oil on the lipid profile in streptozotocin-induced diabetic rats were examined. Materials and Methods: In this study, thirty-two adult male Wistar Albino rats were used. Working groups were consisted as follows: control group (C, n=6), rosemary group (R, n=6), diabetes group (STZ, n=10) and diabetes+rosemary group (STZ+R, n=10). The rosemary oil was administered at oral dosage of 200 mg/kg daily for duration of three weeks in the groups receiving rosemary oil. Diabetes was performed by subcutaneous injections of streptozotocin at dosage of 40 mg/kg in 0.1 M citrate buffer (pH 4.5) for two consecutive days as a single daily dose. At the end of three weeks, blood samples collected from the all animals were assessed lipid parameters. Results: In this study, plasma levels of triglyceride, total cholesterol, and LDLcholesterol significantly elevated, alongside plasma HDL-cholesterol levels in diabetes group significantly reduced compared to the control group. However, upon the application of rosemary oil to streptozotocin-induced diabetic rats, a substantial decrease in plasma triglyceride, total cholesterol, and LDLcholesterol levels was observed, while plasma HDL-cholesterol notably increased. Conclusion: As a result of the current findings, it is concluded that rosemary oil may have antihiperlipidemic properties and could be used as a phytomedicine for the treatment of diabetes. http://eurasianjvetsci.org/pdf.php3?id=1441 Diabeteslipid profileratsrosemary eng Selçuk Üniversitesi Veteriner Fakültesi Eurasian Journal of Veterinary Sciences 1309-6958 2146-1953 2024-03-08 40 1 16 23 1442 article Investigation of prevalence and risk factors of parvovirus infection in dogs in erzurum province, turkey Walied Fadulalseed Ahmed Ismail 1 Basak Hanedan 2 Atatürk University Faculty of Veterinary Medicine, Institute of Health Sciences,Erzurum, TürkiyeAtatürk University Faculty of Veterinary Medicine, Department of Veterinary Internal Medicine, Erzurum, TürkiyeAim: This study aimed to investigate the prevalence and risk factors of canine parvovirus (CPV) infection in dogs that were presented to Animal Hospital of Atatürk University and housed in shelter. Materials and Methods: The samples were obtained from 83 dogs kept animal shelter and 17 dogs presented animal hospital showing clinical signs of CPV infection. The 40 stool samples of 100 dogs (40%) examined by the rapid test were positive for the presence of CPV, and the 60 stool samples (60%) were negative. Results: In this study, it was determined that there was an important association between the presence of CPV and vaccination status, housing place, cleanliness frequency of housing place, anthelmintic treatment as well as anorexia, vomiting, dehydration and abdominal pain findings. Conclusion: All the dogs in this study were young (1.5 to 7.5 months? age range) and had contact with free-roaming stray dogs outside the house and garden. Thus, contact with stray dogs might play an important role in the increased prevalence of CPV. Also, the effective prevention practices should be implemented considering risk factors and common circulation of CPV infection in Erzurum province. http://eurasianjvetsci.org/pdf.php3?id=1442 Canine parvovirusprevalencerisk factors eng Selçuk Üniversitesi Veteriner Fakültesi Eurasian Journal of Veterinary Sciences 1309-6958 2146-1953 2024-03-08 40 1 24 33 1443 article Assessment of the protective effects of pomegranate peel extract and n-acetyl cysteine alone or in combination with ornipural® against cadmium-induced bone toxicity in rat Durmus Hatipoglu 1 İsmail Demircioglu 2 Kursat Filikci 3 Yasemin Korkmaz 4 Huseyin Gungor 5 Muhammed Demircioglu 6 Burak Dik 4 Department of Physiology, Faculty of Veterinary Medicine, Selcuk University, Konya, TürkiyeDepartment of Anatomy, Faculty of Veterinary Medicine, Harran University, Şanlıurfa, TürkiyeDepartment of Pathology, Faculty of Veterinary Medicine, Harran University, Şanlıurfa, Türkiye 4 5Department of Histology and Embryology, Institute of Health Sciences, Dicle University, Diyarbakir, TürkiyeAim: The present study was conducted to determine the effects of pomegranate peel extract (PPE) and N-acetyl Cysteine (NAC) alone or in their treatment combinations with commercial preparation Ornipural® (ORN) on bone metabolism against experimentally cadmium (Cd)-induced toxicity in rats. Materials and Methods: Totally 36 animals were used in the study including 6 Wistar Albino rats in each group. The animals were assigned to control, Cd, Cd+PPE, Cd+NAC, Cd+PPE+ORN and Cd+NAC+ORN groups. The animals in the groups were euthanized after their blood samples were taken at the end of the 8th week. The bones were subjected to maceration for morphometric and histopathological examinations after euthanasia. Results: The statistically significant differences were determined between the treatment groups and Cd group in terms of histopathological changes (osteoporotic alterations and changes in red bone marrow) and biomarkers (Ca, P and Mg) (P<0.05). Conclusion: Although PPE, NAC and treatment combinations with ORN applied against experimentally induced cadmium toxicity were determined to have positive effects on bone metabolism, it has been thought that carrying out trials by increasing treatment duration and dose would be beneficial to determine definite efficacy of the applied treatment protocols. http://eurasianjvetsci.org/pdf.php3?id=1443 Bone toxicitycadmiumN-acetyl cysteineOrnipural®pomegranate peel eng Selçuk Üniversitesi Veteriner Fakültesi Eurasian Journal of Veterinary Sciences 1309-6958 2146-1953 2024-03-08 40 1 34 40 1444 article Effect of hen age on egg quality, hatching performance and chick quality in chukar partridges (alectoris chukar) Mustafa Cam 1 Mahmut Samil Samli 2 Zahit Kutalmis Kaya 31 Halil Harman 4 Abdullah Bilir 4 Kemal Kirikci 1 Selcuk University, Faculty of Veterinary Medicine, Animal Science Department, 42003, Konya, Türkiye 2 3 4Aim: This study was aimed to investigate the effect of different hen ages on egg quality characteristics, hatching performance and chick quality in chukar partridges. Materials and Methods: A total of 510 eggs obtained from chukar partridge flocks were used to determine the effects of different hen age on hatching performance, egg quality traits and chick quality. Daily collected 20 eggs from each age group (1, 2 and 3 years of age) were assessed for internal quality characteristics. A total of 150 eggs per each age group were set into incubator and hatcher set. After hatching, unhatched eggs were broken to determine hatching performance and embryonic mortality. Hatched day-old chicks were scored to determine chick quality characteristics. Results: Internal egg quality traits were not statistically affected by different breeding ages. Different breeding ages did not affect hatchability, early and middle embryonic mortality while late embryonic mortality and fertility of eggs were statistically affected. The evaluated chick quality traits were affected by the different hen age. Conclusion: Despite decreasing fertility rate with age, the results of this study suggest incubating eggs of chukar hens with 3 years age for optimum chick quality and being raised chukar hens up to 3 years of age. http://eurasianjvetsci.org/pdf.php3?id=1444 Tona scorebreeding agehaughhatchability eng Selçuk Üniversitesi Veteriner Fakültesi Eurasian Journal of Veterinary Sciences 1309-6958 2146-1953 2024-03-08 40 1 41 46 1445 article Surgical treatment of paraphimosis in dogs: 4 cases Nuriza Zamirbekova 1 Kurtulus Parlak 1 Iremsu Satici 1 Hilmican Ergin 1 Sena Yazici 1 Ebrar Merve Eris 1 Melek Yildiz 1 Fahrettin Alkan 1 Selcuk University, Faculty of Veterinary Medicine, Department of Surgery, 42003, Konya, TürkiyeAim: The aim of this study was to evaluate the use of surgical methods concerning the severity of persistent paraphimosis and describe the surgical techniques. Materials and Methods: The study material consisted of 4 dogs with paraphimosis. Based on anamnesis and clinical examination, 3 dogs were diagnosed with idiopathic permanent and one dog with traumatic paraphimosis. According to diagnoses and findings, patients underwent preputial advancement, partial penile amputation, phallopexy, and total penile amputation. Results: Recurrence of disease 1 week following surgery was recorded as postoperative complication in the first patient with preputial advancement. Intermittent bleeding in the surgical field in the second patient undergoing partial penile amputation continued for 3 days. No complications were observed as a result of the preputial advancement and phallopexy procedures performed for the treatment of the third case. The surgical wound healing time was recorded as one week in the second and third cases. In the fourth case, intermittent bleeding persisted for 12 days postoperatively and mild dermatitis was noted at the surgical site. According to the information received from the patient owners on the 30th day after the surgery, it was noted that there was no recurrence of the disease and no complications were encountered. Conclusion: According to the results of our study preputial advancement surgery technique alone was unsuccessful when the length of the prolapsed penis from the prepuce was 1,5 cm or more in patients with permanent paraphimosis. In addition, in cases where the disorder of the penile shaft and urethra allows, partial penile amputation should be preferred to total penile amputation. http://eurasianjvetsci.org/pdf.php3?id=1445 Dogparaphimosissurgery