2013, Cilt 29, Sayı 4, Sayfa(lar) 205-210
Antibody responses against foot-and-mouth disease vaccine differ between the sexes in cattle
Murat Şevik
Molecular Microbiology, Veterinary Control Institute, Meram, Konya, Turkey
Keywords: Foot and mouth disease, cattle, vaccination, sex, antibody response
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Aim: The aim of this study was to investigate the effects of sex on the humoral immune response induced in cattle by vaccination against foot-and-mouth disease virus (FMVD).

Materials and Methods: Cattle (n=252) were classified into six groups according to the age (0-11 months, 12-35 months, and >35 months) and sex (male-female). Animals in each group were vaccinated with oil-adjuvanted bivalent vaccine (O1 Manisa, A22 Iraq FMDV strains). Solid-phase competitive ELISA was used to measure antibodies produced in vaccinated cattle.

Results: Serotype O antibody was detected in 86 (68.2%) and serotype A antibody in 90 (71.4%) of 126 male sera. In female animals, serotype O antibody was detected in 106 (84.1%) and serotype A antibody in 112 (88.8%) of 126 sera. Protective level of antibody against serotype O was detected in 89 (70.6%) and serotype A in 98 (77.7%) of 126 female sera. Protective level of antibody against serotype O antibody was detected in 67 (53.1%) and serotype A in 81 (64.2%) of 126 male sera. The differences between the level of protective antibody against both serotype O (P=0.0063) and serotype A (P=0.0259) in female and male animals were statistically significant.

Conclusions: Results showed that female animals vaccinated with oil-adjuvanted bivalent vaccine (containing O1 Manisa, A22 Iraq FMDV strains) had higher antibody responses than male animals. In order to elucidate difference between immune response of male and female animals to FMD vaccination more studies are needed.