2014, Cilt 30, Sayı 1, Sayfa(lar) 044-047
Cerebellar cortical abiotrophy in a Samoyed dog
Mehdi Saberi1, Reza Kheirandish2, Shahrzad Azizi2, Elham Mohebbi3
1Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Iran
2Department of Pathology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Iran
3Modeling in Health Research Center (MHRC), Kerman University of Medical Sciences, Kerman, Iran
Keywords: Samoyed, cerebellar abiotrophy, granular cells, Purkinje cells
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Cerebellar abiotrophies have a non-sex-linked, autosomal, recessively inherited basis in anumber of animal species, and lesions typically reflect progressive loss of Purkinje cells. In this report, ataxia was observed in a one-week-old male Samoyed puppy with no history of trauma or any other illness. Physical examination revealed uncoordinated movements, mild trunkal ataxia and intensive head tremors, so the dog had trouble eating, evacuating and difficulties in standing and walking without falling. The complete cell count, cerebrospinal fluid analysis and cerebral radiographs were normal. Treatment with diazepam, vitamin B1 and glucocorticoids had no effect on clinical signs and the dog died after a month. According to clinical signs and histopathological features, cerebellar cortical abiotrophy was diagnosed. This is the first report of a cerebellar cortical abiotrophy in a Samoyed puppy.