pISSN:1309 - 6958       eISSN:2146 - 1953
1998, Cilt 14, Sayı 2, Sayfa(lar) 131-138
Investigation of The Effects of Combination of Acetylsalicylic Acid and Vitamin C On Functions of Bovine Neutrophils in Vitro Conditions
Ahmet Levent Baş1, Nuri Başpınar2, Muammer Elmas1, Seyfullah Haliloğlu2, Enver Yazar1
1S.Ü. Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, KONYA
2S.Ü. Veteriner Fakültesi, Biyokimya Anabilim Dalı, KONYA
Keywords: acetylsalicylic acid, vitamin C, neutrophil functions, bovine
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In this study, the effects of combination of acetylsalicylic acid (ASA) and vitamin C at dilferent doses on functions of bovine neutrophils (polymorphonuclear leucoyte/PMNL), and the effects of dilferent ASA concentrations on accumulation of vitamin C in neutrophils were investigated. Neutrophils were obtained from six healthy Holstein-heifers in University Dairy Herd. Phagocytic and microbicidal activity of PMNL were measured with fluorescent microscopic technique and intracellular vitamin C levels were detenııined by spectrophotometer. Intracellular vitamin C levels were incerased by combination of ASA and vitamin C at different concentrations, bul this increase was not statistically significant. Furthenmore, phagocytic and microbicidal activity of PMNL were not statistically changed by these combinations.