In this study effects of aflatoxlcosis. which was experimentally induced by giving mixed aflatoxins in teed (2. 5 mg/kg) for 21 days. on phagocytic and Candidacidal activities of chicken peritoneal macrophages and preventive action ol polyvinylpolypyrrolidone (PVPP) supplementation (3g/kg) were investigated. Feeding experiments were performed on totally 200 male one-day-old chicks of Avian strain. The animals were divided into tour groups each containing 50 chickens and feed with different diets as fallows: First group, with commercial broiler feed. Second group, with mixed aflatoxins containing (2.5 mg/kg) commercial broiler feed Third group, with PVPP (0.3 %) supplemented commercial broiler feed. Fourth group, with both PVPP (0.3 %) and mixed aflatoxins (2.5 mg/kg) containing feed At the end of the feeding experiment, peritoneal macrophages were isolated. The phagocytic and intracellular Candidacidal indices were determined. The data were analysed statistically. The results have revealed that allatoxicosls depressed both phagocytic and Candidacidal potential of peritoneal macrophages. PVPP addition prevented the animals from deppressive effects caused by aflatoxins on peritoneal macrophage functions.