Aim: In this study, it is aimed that to be defined the effect of erythromycin and bethanechol which are from prokinetic agent on the value of discharge for the calves that are healthy, diarrheic and premature.

Materials and Methods: In the study, 5 healthy calves, 12 diarrheic calves and 12 premature calves were used. Each of these three groups are divided into three sub groups and it is applied 10 mg/kg IM dose of erythromycin, 0,07 mg/kg IM dose of bethanechol for two sub groups. For the last sub groups, those drugs have not been applied. 50 mg/kg acetaminophen and 25 gram/L glucose have been added in to the substitution of milk to evaluate the speed of gastrointestinal motility with the test results of absorptions of acetaminophen and glucose. The blood examples have been taken before substitution of milk application and for 30, 60, 90, 120, 180, 240 and 300th minutes after substitution of milk application.

Results: The respiratory rates and number of heartbeats were also recorded during the test time. There are no changes was observed in number of heart beats, respiratory rates and general conditions for all groups after drugs applied. It is observed that, the feces of some calves were became slightly watery viscosity and premature calves generally defecated after 180 minutes. When Cmax, Tmax and AUC values of acetaminophen and glucose are compared with control group’s after applying erythromycin on the calves which are in premature group, it is defined the higher Cmax (P<0,05), shorter the Tmax and greater AUC (P>0,05) values.

Conclusion: According to clinical and laboratory findings, it may be stated that the application of 10 mg/kg dose of erythromycin IM has provided faster abomasal emptying in premature calves.