Gelecek Sayı: Haziran 2024
pISSN 1309-6958
eISSN 2146-1953
| 2015, Cilt 31, Sayı 3, Sayfa(lar) 148-151 |
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| Investigation of oxidative stress index in pyridine and ellagic acid treated mice |
| İnan Kaya1, Haci Ahmet Deveci2, Mahmut Karapehlivan3, Abdulsamed Kükürt3 |
| 1Department of Biology, Faculty of Arts and Science, Kafkas University, Kars, Turkey 2Islahiye Vocational School, Gaziantep University, Gaziantep, Turkey 3Departmen of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey |
| Keywords: Mice, pyridine, paraoxonase, oxidative stress, ellagic acid |
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Aim: In the present study, effect of ellagic acid on levels of
paraoxonase (PON1), oxidative stress index (OSI), total antioxidant
(TAS) and total oxidant (TOS) in pyridine intoxication
was investigated.
Material and Methods: In the study, 28 male Swiss albino mice were divided into 4 equal groups as following. Control I (Control group, n:7, 0.9% NaCl, IP, SID, 7 days), Group II was applied with pyridine (n:7, 100 mg/kg, IP, SID, 7 days), Group III was applied with ellagic acid (n:7, 10 mg/kg, SC, SID, 7 days) and Group IV was treated with pyridine (100 mg/kg, IP, SID, 7 days) plus ellagic acid (10 mg/kg, SC, SID, 7 days). Serum PON1 activity, OSI, TAS and TOS levels were determined by spectrophotometric methods at the end of the experiment. Results: OSI and TOS levels significantly increased, whereas serum PON1 activity and TAS levels reduced in pyridine treatment group (Group II) when compared to control group. Conclusion: Ellagic acid may show the protective effects against pyridine-induced oxidative stress. |
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