Aim: The aim of present study was to investigate the seroprevalence and economic significance of hypodermosis in cattles in the Diyarbakır province located in the southeast part of Turkey.

Meterials and Methods: Serum samples were collected from 650 randomly selected cattle in Diyarbakır province between November 2012 and October 2013.

Results: 236 (36.6%) out of 650 serum samples were seropositive for Hypoderma antibodies. It was shown that the highest detected seropositivity rate was in central distinct and that seropositivity rate was higher in females (37%) compared to the male animals (33.3%). Moreover, the seropositivity rates were higher in native (48.8%) compared to the other breeds and in animals older than 5 years (41.6%) compared to younger animals. The estamined economic loss due to the damaged hides was 101.310 Turkish Lira per year (47.563 United States Dollars).

Conclusion: It may be stated that hypodermosis is widespread in the region and it causes substantial economic loss in the hides sector.