2020, Cilt 36, Sayı 5, Sayfa(lar) 076-090 |
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The mysterious of SARS and MERS vaccines, new approaches to a Coronavirus vaccine |
Atilla Şimşek, Oğuzhan Avcı |
Selçuk Üniversitesi Veteriner Fakültesi Viroloji Anabilim Dalı, Konya, Türkiye |
Keywords: Coronavirus, SARS-CoV-2, COVID-19, vaccine |
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COVID-19 pandemic caused by SARS-CoV-2, a new type of
coronavirus that causes severe acute respiratory syndrome
in humans, has caused great concern to humanity and significantly
affected life all over the world. SARS-CoV-2 has
been transmitted to millions of people due to the lack of established
treatments and vaccines. Vaccination applications
in the world are regarded as both the most effective and the
most economical and promising method in the protection
and control of infectious diseases in humans and animals.
The determination of the genome and protein structure of
SARS-CoV-2 in a record-breaking time allowed the development
of prophylactic virus-like particle, subunit, RNA, DNA
and vector vaccines as well as inactivated or attenuated viral
vaccines. In addition, the experiences obtained from SARSCoV,
MERS-CoV which are closely related to this virus, and
animal coronavirus infections, have previously caused epidemics
in humans, and contributed greatly to this process.
The latest coronavirus pandemic has caused universities and
research institutes around the world to change their work
plans. These institutions have entered into a busy schedule
to determine how the disease can be stopped with a specific
vaccine. Currently, many companies, universities and institutes
around the world and in our country have included an
effective vaccine development program against SARS-CoV-2.
In this review, previous experiences with coronavirus vaccines
and current approaches to SARS-CoV-2 vaccine development,
methods and strategies carried out around the
world and vaccine candidates are reviewed.
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