pISSN:1309 - 6958       eISSN:2146 - 1953
2021, Cilt 37, Sayı 4, Sayfa(lar) 252-258
Evaluation of hepatokines, proinflammatory cytokines, oxidative stress and energy related metabolism analytes and hematological parameters in dairy cows with placental retention
Efe Kurtdede1, Erdal Kara2, Taha Burak Elifoğlu3, Ufuk Kaya4
1Ankara University Veterinary Faculty, Department of Biochemistry, Ankara, Turkey
2Kırıkkale University Veterinary Faculty, Department of Internal Medicine, Kırıkkale, Turkey
3Kırıkkale University Veterinary Faculty, Department of Obstetrics and Gynaecology, Kırıkkale, Turkey
4Hatay Mustafa Kemal University Veterinary Faculty, Department of Biostatistics, Hatay, Turkey
Keywords: Hepatokines, oxidative stress, placental retention, cytokines, dairy cows
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Aim: To investigate the serum levels of angiopoietin-like protein 4 (ANGPTL4), fibroblast growth factor 21 (FGF21), interleukin 1 beta (IL-1Β), IL-6, superoxide dismutase (SOD), malondialdehyde (MDA), and energy-related metabolism analytes and hematological parameters in cows with placental retention (PR).

Materials and Methods: In the presented study, blood samples were taken from the coccygeal veins of 10 cows with PR and 10 healthy control cows. All of the samples were analyzed to determine the serum glucose, unesterified fatty acid (NEFA), triglyceride, high-density lipoprotein (HDL), total protein, albumin, aspartate aminotransaminase (AST), SOD, and MDA levels. Blood serum hepatokines, ANGPTL4, FGF21 levels, proinflammatory cytokine response parameters, IL-1 beta, and IL-6 levels were evaluated.

Results: As a result, the increase in serum AST (p < 0.05) indicated altered liver function. During negative energy balance, the serum NEFA levels (p < 0.05) increased, and serum HDL levels (p < 0.05) decreased as indicators of an increased risk of metabolic pathology. Increases in the serum ANGPTL4, FGF21, CRP, and SOD (p < 0.001) and IL-6, MDA, creatine kinase levels (p < 0.05) were evaluated as indicators of the development of effective metabolic, inflammatory, and oxidative stress. The monocyte count was significantly lower (p < 0.05) in the cows with PR.

Conclusion: It was concluded that significant increases in the serum ANGPTL4 and FGF2 levels were associated with energy balance, effective cytokine responses, and oxidative stress in dairy cows with PR.