This study aims to investigate the possible effects of Micromeria congesta (MC) against inflammation and oxidative damage in the liver caused by Lipopolysaccharide (LPS) used in sepsis modeling. A total of 24 animals, 6 Wistar Albino rats in each group, were used in the study. Animals were assigned to control, LPS, LPS+25 mg/ kg MC, LPS+50 mg/kg MC groups. In MC groups plant extract was administered to the animals for 7 days, LPS application was been made on the 7th day and the animals were euthanized 6 hours later. After euthanasia, the liver was examined histopathologically and immunohistochemically. In histopathologic examinations, it was determined that the use of MC at increasing doses against liver toxicity caused by LPS decreased the lesions in the liver. In immunohistochemical examination, it was determined that TNF-? and IL-2 expressions, which are important biomarkers of inflammation, decreased in parallel with the increasing dose compared to the LPS group. In addition, HSP 27 expression, which is a marker of oxidative stress, was also found to decrease with increasing dose of MC extract. It was revealed that MC extract had a protective effect on LPS-induced liver toxicity by reducing inflammation and oxidative stress. More studies are needed for MC to be an alternative in the treatment of sepsis.