pISSN:1309 - 6958       eISSN:2146 - 1953
2004, Cilt 20, Sayı 2, Sayfa(lar) 053-058
Are Fixed Oils Of Urtica Pilulifera L. Protective Against Carboplatin-induced Hepatotoxicity?
Haneli Özbek1, Mustafa Kösem2, Ender Erdoğan3, Nureddin Cengiz3, Fevzi Özgökçe4, Betül Sever5
1Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Farmakoloji Anabilim Dalı, VAN
2Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, VAN
3Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Histoloji Anabilim Dalı, VAN
4Yüzüncü Yıl Üniversitesi Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı, VAN
5Ankara Üniversitesi Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, ANKARA
Keywords: Urtica pilulifera L. Carboplatin, Vitamin C, Vitamin E, Hepatotoxicity
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In this study effects of Urtica pilulifera L. extracts against carboplatin-mduced hepatotoxicity were investigated in rats. Sprague-Dawley rats were divided into five study groups and given isotonic saline solution, cartooplatin, carboplatin+fixed oil of Urtica pilulifera L, carboplalintvitamin C and carboplatin+vitamin E respectively. In histological examination of liver sections none of the groups exhibited pathological changes. The liver injury is evidenced by rise of serum alanine aminotransferase, alkaline phosphatase and indirect bilirubin levels in carboplatin group compared to the controls. The lixed oils of Uriica pilulifera L group displayed significantly lower alanine aminotransferase, alkaline phosphatase and indirect bilirubin levels compared to the carbop latin group. Vitamin C and E displayed similar biochemical changes as fixed oils of Urtica pilulifera L. Fixed oils ol Urtica pilulifera L. appears to be equally effective like vitamin C and vitamin E in alleviating carboplatin-induccd hepatotoxicity.