pISSN:1309 - 6958       eISSN:2146 - 1953
2011, Cilt 27, Sayı 1, Sayfa(lar) 045-058
Pathology of single dose cadmium toxicity and investigations of protective effect of simultaneous chlorpromazine administrations in rats
Tuna Erdem, Fatih Hatipoğlu
Selçuk Üniversitesi, Veteriner Fakültesi, Patoloji AD, Kampüs, Konya, Türkiye
Keywords: Cadmium, toxication, chlorpromazine, pathology
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Aim: This study was carried out to determine pathology of cadmium toxicity and protective effects of chlorpromazine in rats, simultaneously.

Materials and Methods: Totally 64 Sprague-Dawley rats were divided into four equal groups. Isotonic saline (C), cadmium chloride (CD), chlorpromazine (CPZ), cadmium plus chlorpromazine (CDCPZ) were injected as a single dose, respectively. Body weight changes, relative organs weights, hematologic and biochemical values were determined. Macroscopical, histopathological and immunohistochemical findings were also examined.

Results: In the CD and CDCPZ groups, not only the body weights decreased but also significant lesions were seen in the testes and epididymis. Relative testes and epididymis weights decreased and atrophy was seen in these organs. In addition, disseminate and intensity necrosis with vessel lesions in the testes was observed. Corresponding to these changes significant decreases in serum testosterone levels were also observed and the spermatic granulomas were seen in the epididymis. Although liver and kidneys were slightly affected, it was observed that damage in these organs would not cause a significant change in the serum biochemical values.

Conclusion: Chlorpromazine injected simultaneously with cadmium had neither protective nor curative effects against cadmium toxicity. It was thought that studies concerning prevention or treatment of cadmium toxication should be planned for longer time periods to obtain better outcomes.