The alm of this present study was to investigate the effect of vitamin A and E on the antibody titers and blood T lymphocyte percentage in the chicken vaccinated with Gumboro. 750 egg male chickens were used as materials and divided into 1 2 groups; antibody titers and % T lymphocyte values were determined in which blood samples taken according to properly from theese groups. lg G levels measured in 1. (control), 2. and 4. group of vaccinated animals, the results were found according to logarithmic base 5.00 ± 0.56, 1 1.50 ± 1.46, 15.42 ± 0.60 respectively. These results found to be statistically important (P<0 01) The relationship between vitamin A and antibody titers have preseni but titers were suppressed by excess (80.000 lU /kg feed) vitamin A resulted in this study. The thinking about that reduced percentage of T lymphocytes have due to combination A and E vitamins in animal feeds in 5. and 6. groups.