Materials and Methods: In this study, blood samples were taken prior to pregnancy at 1., 2., 3., 4., 5. months of gestation and after parturition from 15 female Saanen goats. Serum malondialdehid and antioxidant activity levels were measured with ELISA reader, whereas biochemical parameters were with autoanalyser.

Results: Malondialdehyde concentration decreased dramatically in gestation and after parturition and it decreased to it's the lowest value at 3. month of gestation (P<0.05). Antioxidant activity concentrations increased gradually and it reached to it's the highest value at 3. month of gestation (P<0.05). A fluctuation was determined in serum liver damage indicators. Serum alanine aminotransferase and aspartate aminotransferase levels determined to be increased at 3. and 5. months whereas gamma glutamyl transferase at 1. month (P<0.05). Blood urea nitrogen levels determined to be increased at 5. month (P<0.05).

Conclusion: It can be suggested that oxidative stress occurs during gestation in goats. However, antioxidant capacity can prevent lipid peroxidation in goats which feed properly.