In December 2019, a new respiratory illness was identified in human in Wuhan and has spread across the world. Causative agent of the novel coronavirus (COVID-19) outbreak soon named as SARS-CoV-2. After World Health Organization has declared global emergency in March 2020, the disease has raised dramatically and over 32.7 million COVID-19 infected cases with 991 000 deaths has been reported until late September 2020. The role of animals either as reservoir or target host has been intensively discussed. It has been suggested that bats may be a possible genetic source in the onset of the disease. However, the determination of the possible intermediate host that may have a role in the transmission of the disease to humans is still exactly unclear. In addition, considering the mutation possibilities for the virus with such a high transmission rate, an increase in the host range or surpassing the interspecies barrier is also a situation that can be encountered. Though epidemiologic role of animals in SARSCoV- 2 outbreak must be monitored intensely. In parallel with the increasing disease rates, the information gained on COVID- 19 infection is updated rapidly as well. In this review article, prospecting possible interactions between animals and COVID-19 outbreaks which highly affected human health is aimed.