Gelecek Sayı: Mart 2025
pISSN 1309-6958
eISSN 2146-1953
| 2024, Cilt 40, Sayı 4, Sayfa(lar) 161-166 | |
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| The Correlation between Neopterin, Myeloperoxidase and Oxidative DNA Damage in Sheep with Natural Babesiosis | |
| Sedat Cetin1, Ahmet Ufuk Komuroglu2, Veysel Yuksek3, Semiha Dede4, Ozlem Orunc Kilinc3, Nazmi Yuksek5 | |
| 1Ankara Yildirim Beyazit University, Vocational School of Health Services, Department of Veterinary Medicine Laboratory and Veterinary Health Program, Ankara, Turkey 2Van Yuzuncu Yil University, Vocational School of Health Services, Department of Pharmacy, Pharmacy Services Program, Van, Turkey 3Van Yuzuncu Yil University, Ozalp Vocational School, Department of Medical Laboratory Technician, Medical Laboratory Technician Program, Van, Turkey 4Van Yuzuncu Yil University, Veterinary Faculty, Department of Biochemistry, Van, Turkey 5Van Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Internal Medicine, Van, Turkey |
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| Keywords: Babesiosis, DNA damage, myeloperoxidase, neopterin, sheep | |
| Abstract | |
Aim: The present study was designed to investigate the correlation between
neopterin, myeloperoxidase (MPO), and DNA damage in sheep naturally
infected with babesiosis. Materials and Methods: The study included 40 sheep Akkaraman, 1-3 years aged, with 20 healthy individuals (control group) and 20 naturally infected with babesiosis (patient group). Blood samples were collected from the jugular vein into biochemical tubes from all sheep. The cause of the disease was confirmed through smear tests and PCR analysis. Neopterin, myeloperoxidase (MPO), and oxidative DNA damage (8-OHdG) levels were measured using an ELISA method. Results: Neopterin and 8-OHdG levels were significantly lower in the control group compared to the patient group (P<0.05). Although myeloperoxidase were higher in the patient group, the difference was not statistically significant (P>0.05) Conclusion: In this study, a significant increase in neopterin and oxidative DNA damage, which are indicators of an immunological response, was observed in sheep with babesiosis. Neopterin in particular can be considered as an important marker of the immunological response to babesiosis. |
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