2020, Cilt 36, Sayı 5, Sayfa(lar) 065-075 |
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Current knowledge on immunopathology and immunology of COVID-19 disease |
Dilek Azkur1, Ahmet Kürşat Azkur2 |
1Kırıkkale Üniversitesi Tıp Fakültesi Dahili Tıp Bilimleri Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Kırıkkale, Türkiye 2Kırıkkale Üniversitesi Veteriner Fakültesi Virolojii Anabilim Dalı, Kırıkkale, Türkiye |
Keywords: COVID-19, immunopathology, SARS-CoV-2 |
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Severe Acute Respiratory Syndrome (SARS) coronavirus
(CoV) 2 spread from the People's Republic of China on
December 31, 2019 and it is called as a coronavirus disease-
2019 (Coronavirus Disease 2019-COVID-19). In this
review, it is aimed to discuss the interaction of SARS-CoV-2
with natural and adaptive immunity in detail with current
articles. Patients with severe COVID-19, it has been reported
that immunological homeostasis is impaired, resulting in
cytokine storm. In COVID-19 patients, increased viral load,
lymphopenia, eosinopenia and decreased platelet count have
been important markers associated with pathology and disease
severity. Protective antibodies decay is faster than our
expectation, indicating that more attention should be paid to
recurrent infections. Therefore, a sustainable and disciplined
fight against COVID-19 is essential until effective, safe vaccines
and antiviral treatments are available.
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