Gelecek Sayı: Aralık 2024
pISSN 1309-6958
eISSN 2146-1953
| 2022, Cilt 38, Sayı 2, Sayfa(lar) 131-136 |
| [ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ] |
| Apoptosis in bovine ocular squamouse cell carcinomas |
| Tuncer Kutlu1, Emin Karakurt2, Uğur Aydın3, Enver Beytut2, İsa Özaydın3, Serpil Dağ2, Özgür Aksoy3, Hilmi Nuhoğlu2, Ayfer Yıldız2 |
| 1Hatay Mustafa Kemal University, Veterinary Faculty, Department of Patology, Hatay, Turkey 2Kafkas University, Veterinary Faculty, Department of Patology, Kars, Turkey 3Kafkas University, Veterinary Faculty, Department of Surgery, Kars, Turkey |
| Keywords: Apoptosis, BOSCC, differentiation, bovine ocular squamous cell carcinoma |
| Downloaded: - Viewed: |
|
Aim: Cell death, especially apoptosis, is one of the most studied topics
regarding cells. Understanding the mechanism of apoptosis in
diseases will help understand the pathogenesis of diseases, as well
as the treatment. This study aims to grade the Bovine ocular squamous
cell carcinoma (BOSCC) and to evaluate apoptosis in tumors
with different anaplastic features.
Materials and Methods: A total of 30 formalin-fixed tumor tissues consisting of 10 poorly-differentiated, 10 moderately-differentiated, and 10 well-differentiated tissues were used to examine apoptosis in BOSCCs. Hematoxylin & eosin (HE) was performed for histopathological examination and TUNEL staining was performed for detection of apoptosis in all BOSCCs. Results: It was determined that apoptosis decreased as the malignancy increased in BOSCCs (p<0.001). Although all the tumors examined were malignant, apoptosis, i.e. controlled cell death, was found to be severe in well-differentiated type and mild in moderate and poorly-differentiated types. Conclusion: It was concluded that this case observed in bovines should be considered in studies on the pathogenesis of cancer and treatment. |
| [ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ] |