2023, Cilt 39, Sayı 1, Sayfa(lar) 025-029
Effect of combined application of ivermectin and praziquantel on oxidative stress and selected biochemical parameters in sheep
Rahmi Canbar1, Muhittin Uslu2, Mustafa Sedat Arslan3, Enver Yazar4
1Necmettin Erbakan University, Veterinary Faculty, Department of Pharmacology and Toxicology, Konya, Turkey
2Yozgat Bozok University, Sefaatli Vocational School, Laboratory and Veterinary Health Program Yozgat, Turkey
3Selcuk University, Veterinary Faculty, Prof. Dr. Humeyra Ozgen Research and Application Farm, Konya, Turkey
4Selcuk University, Veterinary Faculty, Department of Pharmacology and Toxicology, Konya, Turkey
Keywords: Ivermectin, praziquantel, oxidative stress, biochemical parameters, sheep
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Aim: Purpose of this research was to determine the combined effect of the oral administration of ivermectin and praziquantel on the oxidative status, liver and kidney function parameters in healthy sheep.

Materials and Methods: Ivermectin + praziquantel tablets at the recommended dose (1 tablet/sheep) were administered orally to 18 Anatolian Merino sheep, and blood samples were obtained before administration (day 0) and at 24-hour intervals for 4 days thereafter. Plasma 8-hydroxy- 2-deoxyguanosine, malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase levels were measured with commercial kits using an ELISA reader. Serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine and blood urea nitrogen levels were measured in an autoanalyzer.

Results: While the plasma 8-hydroxy-2-deoxyguanosine levels in the first 2 days were higher than the values on the 3rd and 4th days (p<0.05), statistical fluctuations were observed in the plasma glutathione peroxidase levels (p<0.05). An increased level of blood urea nitrogen was present on day 3 compared to day 0 (p<0.05).

Conclusion: It can be stated that the recommended dose of ivermectin + praziquantel does not cause oxidative stress and has no significant effect on their liver and kidney function parameters in healthy sheep.