In the study, the effects of aspirin and garlic powder supplementation on some electrocardiographic parameters in hypercholesterolaemic rabbits were investigated. Although the plasma cholesterol-rich ration for 4 weeks significantly (p<0.05) increased as compared with the control group, the plasma cholesterol levels in Ihe group supplemented with garlic powder was found to be significantly lower than in both the group received the cholesterol-rich ration alone and the group fed the ration with aspirin {p<0.05),The heart rates in the control group ( 252.7 ) and in the groups supplemented with garlic ( 286.0 ), aspirin ( 271.7 ) and lonely cholesterol ( 276.3 ) were not significantly different from each other .The duration and voltages of P, QRS and T waves measured in lead II and Ihe durations of P-Q and Q-T intervals in the same lead showed no significant difference between groups.lt was not also determined any changes in respect of the shape and position of the waves in all leads of the treatments as compared those in the control group.