Son Sayı: 2025 (Yıllık Cilt - Sürekli yayın modeli)
pISSN 1309-6958
eISSN 2146-1953
pISSN 1309-6958
eISSN 2146-1953
| 2010, Cilt 26, Sayı 1, Sayfa(lar) 021-024 |
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| Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice |
| Ender Yarsan1, Arif Altıntas2, Dinc Essiz3, Levent Altintas1, Mert Pekcan2, Gulay Ciftci4, Ishraga G. Ibrahim5 |
| 1Department of Pharmacology and Toxicology, Ankara University, Faculty of Veterinary Medicine, Diskapi, Ankara, Turkey 2Department of Biochemistry, Ankara University, Faculty of Veterinary Medicine, Diskapi, Ankara, Turkey 3Department of Pharmacology and Toxicology, Kafkas University, Faculty of Veterinary Medicine, Kars, Turkey 4Department of Biochemistry, Ondokuz Mayis University, Faculty of Veterinary Medicine, Samsun, Turkey 5Central Veterinary Research Laboratories, Khartoum, Sudan |
| Keywords: Sulphamethoxazole, pharmacokinetic, renal failure, mercury chloride |
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Aim: The effects of renal failure on the pharmacokinetics
of sulphamethoxazole were investigated after oral administration
of 100 mg/kg of the drug using a mice model of
mercury chloride-induced renal failure.
Materials and Methods: Mercury chloride was given to
mice at the doses of 3 and 6 mg/kg. Plasma sulphamethoxazole
concentrations were measured by spectrophotometer.
Plasma concentration-time data were fitted to a two-compartment
open model.
Results: Significant findings (p<0.05) were observed for
absorption (AUC and t1/2a) and elimination (t1/2β and MRT)
phases of sulphamethoxazole related with renal failure.
Also area under the curve value decreased, and mean residence
time value increased with renal failure (p<0.05).
Conclusion: Study result showed that dosage and administration
intervals of sulphamethoxazole were important for
patients with renal failure.
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