Severe Acute Respiratory Syndrome (SARS) coronavirus (CoV) 2 spread from the People's Republic of China on December 31, 2019 and it is called as a coronavirus disease- 2019 (Coronavirus Disease 2019-COVID-19). In this review, it is aimed to discuss the interaction of SARS-CoV-2 with natural and adaptive immunity in detail with current articles. Patients with severe COVID-19, it has been reported that immunological homeostasis is impaired, resulting in cytokine storm. In COVID-19 patients, increased viral load, lymphopenia, eosinopenia and decreased platelet count have been important markers associated with pathology and disease severity. Protective antibodies decay is faster than our expectation, indicating that more attention should be paid to recurrent infections. Therefore, a sustainable and disciplined fight against COVID-19 is essential until effective, safe vaccines and antiviral treatments are available.