2024, Cilt 40, Sayı 1, Sayfa(lar) 001-009 | |
[ Özet ] [ PDF ] [ Benzer Makaleler ] [ Yazara E-Posta ] [ Editöre E-Posta ] | |
Potential therapeutic effect of Thymoquinone on Cisplatin-induced hepatotoxicity in rats | |
Sercan Kaya, Tuba Yalcin | |
Batman University, Vocational School of Healthcare Studies, Batman, Türkiye | |
Keywords: Hepatotoxicity, otulin, cisplatin, thymoquinone | |
Abstract | |
Aim: Cisplatin (CIS), an antineoplastic agent, shows serious side effects such
as hepatotoxicity. Thymoquinone (ThQ) is a powerful anti-oxidant with many
beneficial effects such as anti-inflammatory, anti-tumoral. The aim of this
study was to investigate whether ThQ treatment has hepatoprotective effect
in CIS-induced hepatotoxicity model in rats and also to determine how CIS
and/or ThQ treatments affect OTULIN levels, one of the deubiquitinases, in
liver tissue. Materials and Methods: The 28 rats used in the study control (application not done), CIS (7 mg/kg CIS, first day of experiment, intraperitoneal), CIS+ThQ (7 mg/kg CIS, first day of experiment, intraperitoneal + 10 mg/kg/day ThQ, oral gavage) and ThQ (10 mg/kg/day ThQ, oral gavage) were divided into four equal groups (n=7). The experiment was terminated upon completion of all applications (day 15). The effects of CIS and\or ThQ apps on liver tissues were examined biochemically, histopathologically and immunohistochemically. Results: CIS application increased liver enzyme levels, histopathological changes, inflammation, oxidative stress and apoptosis in liver tissue and caused a decrease in OTULIN level. However, ThQ administration showed a positive regulatory effect on CIS-induced changes in liver tissue.. Conclusion: ThQ supplementation has a hepatoprotective effect against CISinduced liver tissue damage. |
|
[ Başa Dön ] [ Özet ] [ PDF ] [ Benzer Makaleler ] [ Yazara E-Posta ] [ Editöre E-Posta ] |